Dietary nucleotides have cytoprotective properties in rat liver damaged by thioacetamide
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چکیده
منابع مشابه
Dietary nucleotides have cytoprotective properties in rat liver damaged by thioacetamide.
Liver cirrhosis has been induced with thioacetamide administered via different routes in rats and other species. The oral intake of thioacetamide causes nodular liver cirrhosis in rats characterized by extensive fibrosis occupying most of the hepatic parenchyma. To characterize the cytological features of cirrhosis induced by thioacetamide, and the degree of recovery obtained with dietary nucle...
متن کاملLiver nucleotides in acute experimental liver injury induced by dimethylnitrosamine and by thioacetamide.
1. The concentrations of the nicotinamide-adenine dinucleotides in rat liver have been determined at intervals during the period 1-24hr. after feeding adult female rats with dimethylnitrosamine or thioacetamide. 2. The administration of dimethylnitrosamine resulted in a rapid decrease in the sum of NAD+NADH(2). This sum was decreased by 40% 3hr. after dosing. 3. Dimethylnitrosamine administrati...
متن کاملEffect of Thioacetamide on Rat Liver Regeneration
The effect of thioacetamide on dividing cells of regenerating rat liver has been studied. Rats were given daily subcutaneous injections of thioacetamide as a 1 per cent solution at a dosage of 5 mg./100 gm. body weight for 7 to 10 days, subjected to partial hepatectomy, and sacrificed 28 to 31 hours later. Thioacetamide treatment results in striking increases in the nuclear ribonucleoproteins o...
متن کاملEffect of Thioacetamide on Rat Liver Regeneration
The effect of thioacetamide on dividing cells of regenerating rat liver has been studied. Rats were given daily subcutaneous injections of thioacetamide as a 1 per cent solution at a dosage of 5 rag./100 gm. body weight for 7 to I0 days, subjected to partial hepatectomy, and sacrificed 28 to 31 hours later. Thioacetamide treatment results in striking increases in the nuclear ribonucleoproteins ...
متن کاملDietary nucleotide supplementation reduces thioacetamide-induced liver fibrosis in rats.
Dietary nucleotides reportedly promote functionality and repair in fibrotic liver. Liver fibrosis is characterized by an excessive accumulation of extracellular matrix components, which lead to the impairment of the hepatic function. The aim of this work was to evaluate the influence of dietary nucleotides on liver fibrosis induced by thioacetamide and to elucidate the mechanism by which nucleo...
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ژورنال
عنوان ژورنال: Life Sciences
سال: 1997
ISSN: 0024-3205
DOI: 10.1016/s0024-3205(97)01033-3